Process for preparing 1,2,5-thiadiazoles

Details Process for preparing 1,2,5-thiadiazoles Process for preparing 1,2,5-thiadiazoles

1983-03-16

1984-04-03

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546209, 546256, 546277, 548134, 548135, 548127, 544 60, 544124, 544134, 544360, 544364, 544367, 2602455, C07D28510

Patent

active

044409338

ABSTRACT:
Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula ##STR2## with a compound of the formula

REFERENCES:
patent: 4374248 (1983-02-01), Crenshaw et al.
patent: 4380638 (1983-04-01), Crenshaw et al.
patent: 4380639 (1983-04-01), Crenshaw et al.
patent: 4394508 (1983-07-01), Crenshaw et al.
Harpp et al., "Tetrahedron Letters", No. 15, pp. 1481-1484, (1972).
Weinstock et al., "J. Organic Chem.", vol. 32, pp. 2823-2829, (1967).
Kalnins, "Canadian J. Chem.", vol. 44, pp. 2111-2113, (1966).
Harpp et al., "J. Am. Chem. Soc.", vol. 100, pp. 1222-1228, (1978).
Sosnovsky et al., "Liebig's Ann der Chemie", pp. 121-136, (1982).

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