Process for preparing 1,2,4-triazole-3-carboxamides

Details Process for preparing 1,2,4-triazole-3-carboxamides Process for preparing 1,2,4-triazole-3-carboxamides

1984-04-13

1986-03-25

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544132, 544366, 546210, 548518, C07D24914, C07D40106, C07D40306, C07D41306

Patent

active

045784795

ABSTRACT:
There is disclosed a process for preparing a 1,2,4-triazole-3-carboxamide represented by the formula: ##STR1## wherein, R.sup.1 and R.sup.2 represent independently a hydrogen atom, an alkyl group, a cycloalkyl group or an aryl group, or both R.sup.1 and R.sup.2 represent an alkylene group linked with each other directly or through an oxygen atom or a nitrogen atom to form a ring together with the nitrogen atom to which they are attached,
which comprises subjecting an oxamohydrazide represented by the formula: ##STR2## wherein R.sup.1 and R.sup.2 have the same meanings as defined above,
to reaction with formamidine or a salt thereof.

REFERENCES:
Poonian et al.: Novel Precursor for Synthesis of C-Nucleoside Analogues of Ribavirin, J. Org. Chem. 45 (2) 1980, pp. 203-208.
Poonian et al.: A Total Synthesis of C-Nucleoside Analogues of Virazole, J. Org. Chem., vol. 42 (6) 1977, pp. 1109-1110.
Huynh-Dinh et al.: Synthesis of C-Nucleosides, Part 14 (1,2-4 Triazole Carboxamides) J. Chem. Soc. Perkin Trans I (7), 761-764, 1977.
Temple, Jr. et al.: Chem of Heterocyclic Cupds.-Triazoles 1,2,4: Carboxylic Acid and Deriv., pp. 96-97; 1981, John Wiley and Sons.
March: Advanced Organic Chem.: R.sub.x, Mechanisms & Struct., 1977, 2nd Ed., pp. 914-917, 322-326.

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