Process for preparing 1,2,4-thiadiazole derivatives

Details Process for preparing 1,2,4-thiadiazole derivatives Process for preparing 1,2,4-thiadiazole derivatives

1994-04-11

1996-12-17

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D28508

Patent

active

055854940

ABSTRACT:
An improved process for the production of 5-amino-1,2,4-thiadiazol-3-yl-(2-(lower)-alkoxyimino)acetic acids starting from 5-substituted- or unsubstituted-3-amino-isoxazole compounds is disclosed herein. The title compounds are useful as acylating agents for the production of 7-acylaminocephalosporins.

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Vivona, N., et al, Journal of the Chemical Society Perkin Transactions 1, Letchworth GB, 1616-1619 (1977).
Zayed, E. M., et al, Chemical Abstracts 98:143312n (1983).
Stridevi, G., et al, Chemical Abstracts 111:7293s (1989).
Macaluso, Heterocycles 24, 3433 (1986).
March, Advanced Organic Chemistry, 629-631 (1985).

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