Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,

Details Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1, Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,

1995-03-30

1997-03-18

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540472, C07D25702

Patent

active

056124783

ABSTRACT:
An improved process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane.

REFERENCES:
patent: 5021409 (1991-06-01), Murrer et al.
patent: 5047527 (1991-09-01), Handel et al.
patent: 5247075 (1993-09-01), Parker et al.
patent: 5326861 (1994-07-01), Madison et al.
J. Med. Chem., vol. 38, No. 2, pp. 366-378 (1995).
Bridger et al, Journal of Medicinal Chemistry, vol. 38, No. 2, pp. 366-378 (Jan. 20, 1995).
Chemical Abstracts, vol. 107, No. 18, Abstract No. 167695 (Nov. 2, 1987).
Brandes et al, Bulletin de la Societe Chimique de France, vol. 133, No. 1, pp. 65-73 (1996).

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