Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2007-10-16
2007-10-16
Witherspoon, Sikarl A. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S084000
Reexamination Certificate
active
11179568
ABSTRACT:
The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(−)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where R1and R2represent C1-C4alkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts.Tamsulosin hydrochloride (R1=Et, R2=Me, in its hydrochloride salt form) is an antagonist of α-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.
REFERENCES:
patent: 2006/0036113 (2006-02-01), Xie
patent: WO2004/087623 (2004-10-01), None
Chakraborty Subhasish K.
Chang Wei Min
Das Asish R.
Jih Ru Hwu
Lu Chin Kun
Rosenberg , Klein & Lee
Taiwan Biotech Co., Ltd.
Well-Being Biochemical Corp.
Witherspoon Sikarl A.
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