Process for preparation of substantially optically pure...

Details Process for preparation of substantially optically pure... Process for preparation of substantially optically pure...

2007-06-15

2011-12-27

Jarrell, Noble (Department: 1622)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

08084606

ABSTRACT:
The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine intermediate, 1-[(4-chlorophenyl)phenylmethyl]piperazine, thereby producing substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine and their pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates.

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Wang, et al., Synthesis of (+)-2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochoride (Levocetirizine), Guangxi Daxue Xuebao, Ziran Kexueban, 32(4), 384-386 (2007).
Notification of Transmittal of the International Search Report and The Written Opinion of the International Searching Authority, or the Declaration.

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