Process for preparation of racemate and optically active ofloxac

Details Process for preparation of racemate and optically active ofloxac Process for preparation of racemate and optically active ofloxac

1986-04-25

1988-10-11

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 586, 544 73, 540575, 546156, 560 39, C07D49806

Patent

active

047772530

ABSTRACT:
A process for producing racemic or optically active compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 to C.sub.6 alkyl or benzyl; and Z is amino or substituted amino.
Also disclosed are intermediates useful in the process and methods for producing the intermediates.

REFERENCES:
patent: 4571396 (1986-02-01), Hutt et al.
Drugs of the Future, vol. 8, No. 5 (1983), pp. 395-396.
Hayakawa et al, Antimicrobial Agents and Chemotherapy, Jan. 1986, pp. 163-164.
Hayakawa et al, Chem. Pharm. Bull., vol. 32, No. 12 (1984), pp. 490-4913.
March, Advanced Organic Chemistry: Reactions, Mechanisms, and Structures, McGraw-Hill, NY (1968), pp. 331, 332 & 500.

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