Process for preparation of pyridine derivatives of NK-1...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S235500, C514S252130, C544S058200, C544S111000, C544S361000

Reexamination Certificate

active

07384939

ABSTRACT:
The present invention provides a process for preparing a pyridine compound of the formula:wherein R1, R2, R3and a are those defined herein.

REFERENCES:
patent: 3853895 (1974-12-01), Lamm et al.
patent: 4061642 (1977-12-01), Fleckenstein et al.
patent: 4182887 (1980-01-01), Roch et al.
patent: 2005/0014792 (2005-01-01), Goehring et al.
patent: 10008042 (2000-08-01), None
patent: 1103545 (2003-05-01), None
patent: 1103546 (2003-10-01), None
patent: 02/06236 (2002-01-01), None
patent: 02/08232 (2002-01-01), None
patent: 02/16324 (2002-02-01), None
patent: 02/47663 (2002-06-01), None
patent: 02/079134 (2002-10-01), None
patent: 02/085458 (2002-10-01), None
patent: 03/006016 (2003-01-01), None
patent: 03/011860 (2003-02-01), None
patent: 03/064685 (2003-08-01), None
patent: 04/067007 (2004-08-01), None
patent: 06/002860 (2006-01-01), None
patent: 06/099968 (2006-09-01), None
Hcaplus 74:53461.
Harrington, Peter J. et al., “Research and Development of an Efficient Process for the Construction of the 2,4,5-Substituted Pyridines of NK-1 Receptor Antagonists”, Organic process Research & Development, 2006:10, pp. 1157-1166.
Hoffmann-Emery et al., “Efficient Synthesis of Novel NK1 Receptor Antagonists: Selective 1,4-Addition of Gridnard Reagents to 6-Chloronicotinic Acid Derivatives”, Journal of Organic Chemistry, 2006, vol. 71, No. 5, pp. 2000-2008.
Hoffmann, Torsten et al., “Design and Synthesis of a Novel, Achiral Class of Highly Potent and Selective, Orally Active Neurokinin-1 Receptor Antagonists”, Bioorganic & Medicinal Chemistry Letters 16 (2006), pp. 1362-1365.
Humpries, Mark J., et al., “A Fresh AIR Synthesis”, Synthesis 1999, No. 6, pp. 985-992.
Katritzky, Alan R., et al., “Preparation of Tetrahydroindolizines from Pyridinium and Isoquinolinium Ylides”, J.C.S. Perkin I, 1981, pp. 1180-1185.
Litvinov, V.P., et al., “Pyridinium Ylides in Organic Synthesis. Part 4. Pyridinium Ylides in Nucleophilic Addition-Elimination (Adn-e) Reactions”, Russian Journal of Organic Chemistry, vol. 33, No. 7, 1997, pp. 903-940. Translated from Zhurnal Organicheskoi Khimii. vol. 33, No. 7, 1997, pp. 975-1014. Original Russian Text Copyright 1997 by Litvinov, Shessopalov.
Merchant, Kevin J., “Potassium Trimethylsilanolate Mediated Hydrolysis of Nitriles to Primary Amides”, Tetrahedron Letters 41 (2000), pp. 3747-3749.
Miyamoto, Teruyuki et al., “Synthesis and Reactions of 7-Substituted 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acids as an Antibacterial Agent [1]”, Journal of Heterocyclic Chemistry, vol. 24, Sep.-Oct. 1987, pp. 1333-1339.
Salem, Mounir A. I., et al., “Synthesis of Bactericides Via Carbon Nucleophilic Addition on 1,3-Diarylprop-2-enoned as Michael Acceptors”, Heterocycles, vol. 53, No. 5, 2000, pp. 1129-1143.
Shestopalov, Yu et al., “Stereochemistry of the Reaction of Pyridinium Ylides With alpha, beta-unsaturated Nitriles”, T. G. Shevchenko State Pedagogical Institute, Lugansk 348011. N.D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow 117913. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 363-369, Mar. 1990. Original article submitted Jul. 25, 1988, revision submitted Jan. 18, 1989.
Shestopalov, A.M., et al., “Stereoselective Synthesis of trans-4,5-Substituted 1,4,5,6-tetrahydropyridine-2-(olates) thiolates”, Synthesis, May 1991, pp. 402-404.
Stout, Steven C., “Neurokinin1 Receptor Antagonists as Potential Antideppressants”, Annu. Rev. Pharmacol. Toxicol. 2001.41:877-906.

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