Process for preparation of pyridine derivatives

Details Process for preparation of pyridine derivatives Process for preparation of pyridine derivatives

2007-10-30

2007-10-30

Davis, Zinna N. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C544S060000, C544S124000, C544S360000

Reexamination Certificate

active

10888912

ABSTRACT:
The present invention relates to a process for the manufacture of compounds of formulawherein the substituents are as described hereinwhich comprises the steps ofa) reacting a compound of formulawith a compound of formulato form a compound of formulab) converting the OH/═O function of compounds of formula XIV/XIVa into a leaving group P with a reagent containing a leaving group, selected from POCl3, PBr3, MeI and (F3CSO2)2O to form a compound of formulawherein P is halogen or trifluoromethanesulfonate;c) substituting R2for the leaving group P by reacting compound XV with HR2to form a compound of formulaandd) hydrolyzing the nitrile function in an acidic medium selected from H2SO4, HCl and acetic acid, to form a compound of formula IThe compounds of formula I are valuable intermediates for the manufacture of therapeutically active compounds which have NK-1 antagonist activity.

REFERENCES:
patent: 4745123 (1988-05-01), Butler et al.
patent: 4764361 (1988-08-01), Bilski et al.
patent: 5387595 (1995-02-01), Mills et al.
patent: 5554633 (1996-09-01), Teall
patent: 5612337 (1997-03-01), Baker et al.
patent: 5719147 (1998-02-01), Dorn et al.
patent: 5972938 (1999-10-01), Rupniak
patent: 6294537 (2001-09-01), Bichon et al.
patent: 6297375 (2001-10-01), Bös et al.
patent: 6479483 (2002-11-01), Bös et al.
patent: 089 765 (1983-09-01), None
patent: 0 235 663 (1987-09-01), None
patent: 244 080 (1987-11-01), None
patent: 244 937 (1987-11-01), None
patent: 359 547 (1990-03-01), None
patent: 385 350 (1990-09-01), None
patent: 405 931 (1991-01-01), None
patent: 427 526 (1991-05-01), None
patent: 524 781 (1993-01-01), None
patent: 638 557 (1995-02-01), None
patent: 0 733 632 (1996-09-01), None
patent: 1 035 115 (2000-09-01), None
patent: 1 103 545 (2001-05-01), None
patent: 1 103 546 (2001-05-01), None
patent: 2 029 801 (1992-10-01), None
patent: 1 557 420 (1979-12-01), None
patent: 8101320 (1981-10-01), None
patent: 8101697 (1981-10-01), None
patent: WO92/06080 (1992-04-01), None
patent: WO93/11110 (1993-06-01), None
patent: WO94/21611 (1994-09-01), None
patent: WO94/27604 (1994-12-01), None
patent: WO95/16679 (1995-06-01), None
patent: WO95/18124 (1995-07-01), None
patent: WO95/23798 (1995-09-01), None
patent: WO96/00213 (1996-01-01), None
patent: WO95/33744 (1996-12-01), None
patent: WO97/19926 (1997-06-01), None
patent: WO97/36871 (1997-10-01), None
patent: WO98/21185 (1998-05-01), None
patent: WO 00/50398 (2000-08-01), None
patent: WO 02/08232 (2002-01-01), None
Barker, Reviews in the Neurosciences, vol. 7, No. 3, pp. 187-214 (1996).
Longmore et al., Can. J. Physiol. Pharmacol., vol. 75, pp. 612-621 (1977).
Kramer et al., Science, vol. 281, pp. 1640-1645 (1998).
Maggi et al., J. Auton Pharmacol., vol. 13, pp. 23-93 (1993).
Navari et al., New England Journal of Medicine, vol. 340(3), pp. 190-195 (1999).
Abstract corresponding to WO 96/00213.
Abstract corresponding to WO 94/27604.
Ikeura et al., Chem. Phar. Bull., vol. 45(10), pp. 1642-1652 (1997).
Natsurgari et al., J. Med. Chem., vol. 38(16), pp. 3106-3120 (1995).
Abstract corresponding to WO 98/21185.
Katritzky, A. R. et al., J. C. S. Perkin I, 1981 pp. 1180-1185.
Hosoki R. et al., European Journal of Pharmacology vol. 341, pp. 235-241 (1998).

Affiliated with

Also associated with

Rating

Process for preparation of pyridine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparation of pyridine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of pyridine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3881092