Process for preparation of piperidyl-indoles

Details Process for preparation of piperidyl-indoles Process for preparation of piperidyl-indoles

1979-12-06

1980-11-04

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546273, C07D40104, A61K 3140

Patent

active

042320313

ABSTRACT:
A novel process for the preparation of piperidylindoles of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms and X is selected from the group consisting of hydrogen, nitro, fluorine, bromine, chlorine and alkoxy of 1 to 3 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts thereof by reacting an indole of the formula ##STR2## with 4-piperidone hydrochloride in an alkaline medium to obtain the compound of formula I which is optionally salified and the novel product, 5-nitro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and its non-toxic, pharmaceutically acceptable acid addition salts.

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patent: 3850938 (1974-11-01), Derible et al.
patent: 3950527 (1976-04-01), Derible et al.
patent: 3980658 (1976-09-01), Possanza et al.
patent: 3993764 (1976-11-01), Dumont et al.
Freter, J. Org. Chem., vol. 40, 2525-2529 (1975).
Freter, Chem. Abst., vol. 83, Abst. 131396v, (1975).
Clemence et al, Chem. Abst., vol. 88, Abst. 62398m (1978).

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