Process for preparation of physiologically active peptides

Details Process for preparation of physiologically active peptides Process for preparation of physiologically active peptides

1978-06-16

1979-09-11

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435886, A61K 3574, C12D 1306

Patent

active

041674480

ABSTRACT:
The present invention relates to new physiologically active peptides, derivatives thereof and a process for preparation thereof. In particular, it relates to new tetrapeptides designated amastatins A.sub.1, A.sub.2, A.sub.3, B.sub.1 and B.sub.2 and derivatives thereof which have an inhibitory effect on aminopeptidase A and also show stimulation of antibody formation and to a process for preparation thereof by cultivating a strain belonging to the genus Streptomyces.

REFERENCES:
patent: 3869347 (1975-03-01), Umezawa et al.
patent: 3878185 (1975-04-01), Murao et al.
patent: 4029547 (1977-06-01), Umezawa et al.
patent: 4070458 (1978-01-01), Umezawa et al.
Aoyagi et al., Journal of Antibiotics, vol. 31, No. 6, pp. 636-638, (Jun. 1978).
Journal of Antibiotics, vol. 29, pp. 97-103, (Jan. 1976), pp. 600-601, (May 1976).

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