Process for preparation of phthalide derivatives

Details Process for preparation of phthalide derivatives Process for preparation of phthalide derivatives

1985-03-05

1987-08-04

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 90, 546147, C07D40504, C07D40514

Patent

active

046847324

ABSTRACT:
Disclosed herein is a process for preparing phthalide derivatives represented by the general formula (IV): ##STR1## wherein R.sup.1 to R.sup.7 are herein defined, comprising (i) reacting a nitrophthalide of the general formula (I) defined herein with an isoquinoline of the general formula (II) defined herein, and (ii) reducing the resultant phthalideisoquinoline of the general formula (III) defined herein. The process is characterized in (A) that the reaction defined in (i) is carried out in methanol, and/or (B) that the nitrophthalide of the general formula (I) is a nitrophthalide obtained by a reaction of a phthalide of the general formula (V) defined herein with copper nitrate or zinc nitrate.

REFERENCES:
patent: 3989704 (1976-11-01), Houlihan et al.
patent: 4175191 (1979-11-01), Houlihan et al.

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