Process for preparation of penam derivatives from cepham...

Details Process for preparation of penam derivatives from cepham... Process for preparation of penam derivatives from cepham...

2005-08-30

2005-08-30

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06936711

ABSTRACT:
The present invention relates to a process for preparing 2α-methyl-2β-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2β-heterocyclyl methyl penam derivatives of the formula (I)by reacting a cepham compound with a heterocylic amine to form an intermediate compound, and oxidizing the intermediate compound to produce the 2β-heterocyclyl methyl penam derivatives of the formula (I), wherein R1represents carboxylic acid protecting group; R2and R3may be same or different and independently represent hydrogen, halogen, NH2, acylamino, phthalimido with a proviso that both R2and R3are not NH2, acylamino, phthalimido; Het represents a 5 or 6 membered nitrogen containing heterocycle ring system having one or more heteroatoms selected from O, S, or N.

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