Process for preparation of optically pure or optically...

Details Process for preparation of optically pure or optically... Process for preparation of optically pure or optically...

2007-01-30

2007-01-30

McKenzie, Thomas (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S338000, C514S393000, C514S395000, C546S273100, C546S273400, C546S273700, C546S183000

Reexamination Certificate

active

10608781

ABSTRACT:
A process of preparation of optically pure or optically enriched isomers of omeprazole and structurally related sulfoxides is provided. Also provided are an amorphous form of esomeprazole, as well a pharmaceutical composition containing it and a method of using it for treatment of gastric disorders.

REFERENCES:
patent: 6262085 (2001-07-01), Whittle et al.
patent: 6369087 (2002-04-01), Whittle et al.
patent: 9602535 (1996-02-01), None
patent: 9828294 (1998-07-01), None
patent: 9854171 (1998-12-01), None
Eberle, D. et al. “Chiral resolution of pantoprazole sodium and related sulfoxides by complex formation with bovine serum albumin in capillary electrophoresis” Journal of Chromatography A, 759, (1997) pp. 185-192.
Komatsu N. et al. “Kinetic Resolution of Sulfoxides Catalyzed by Chiral Titanium-Binaphthol Complex” J. Org. Chem. 58, (1993) pp. 7624-7626.

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