Process for preparation of o-(2,6-dichloroanilino)phenylacetic a

Details Process for preparation of o-(2,6-dichloroanilino)phenylacetic a Process for preparation of o-(2,6-dichloroanilino)phenylacetic a

1979-08-07

1981-08-11

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

564163, 564168, 562456, 546226, 544391, 2603265E, 260544D, C07C 5106, C07C10200, C07D29518

Patent

active

042835321

ABSTRACT:
Disclosed is a process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid (Diclofenac) or its pharmacologically acceptable acid addition salt, which comprises hydrolyzing an N,N-disubstituted-o-(2,6-dichloroanilino)phenylacetamide derivative with an alkali. Also a novel intermediate for use in the preparation of Diclofenac, that is, an N,N-disubstituted-o-halogenophenylacetamide in which the halogen is iodine or bromine, is disclosed.

REFERENCES:
patent: 2553914 (1951-05-01), Goldberg
patent: 3390172 (1968-06-01), Schever
patent: 3590039 (1971-06-01), Sallmann et al.
Folia Pharmacologica Japanica, vol. 69, pp. 299-318, (1973).
MeOmie, "Protective Groups in Organic Chemistry," p. 191, (1974).
Alhede et al., Chem. Abst., vol. 72, p. 305,#12408p (1970).
Morris et al., Organic Chem., pp. 670-671, (1966).

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