Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1991-12-19
1992-11-10
Shippen, Michael L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C07C20500
Patent
active
051625725
ABSTRACT:
An improved process for preparing alkyl nitroacetates by the gradual addition of nitric acid to a reaction vessel having therein a solution of alkyl nitroacetate and a carboxylic acid anhydride, optionally in the presence of an acid catalyst, at low temperatures to form an alkyl nitroacetoacetate intermediate which can thereafter be cleaved with a nucleophile to form an alkyl nitroacetate.
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Arndt and Rose, J. Chem. Soc., p. 6 (1935).
Finkbeiner et al., J. Org. Chem., 28, 215-217 (1963).
Kornblum et al., J. Am. Chem. Soc., 77, 6654-5 (1955).
Johnson Beverly K.
Shippen Michael L.
W.R. Grace & Co.-Conn.
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