Process for preparation of N.sup.6 -substituted 3',5'-cyclic ade

Details Process for preparation of N.sup.6 -substituted 3',5'-cyclic ade Process for preparation of N.sup.6 -substituted 3',5'-cyclic ade

1985-04-25

1988-06-14

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536 26, 536 28, C07H 1512, C07H 1700

Patent

active

047512938

ABSTRACT:
A method for the preparation of an N.sup.6 -substituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR1## wherein R.sub.1 represents a straight chain or branched chain alkyl group of 1 to 13 carbon atoms or an aromatic group and B.sym. represents a hydrogen ion or an alkali metal ion, which comprises allowing a 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR2## wherein A.sym. represents a hydrogen ion, alkali metal ion, organic ammonium ion, or ammonium ion, to react with an aldehyde represented by the general formula

REFERENCES:
patent: 4044123 (1977-08-01), Daniels et al.
patent: 4567254 (1986-01-01), Kataoka et al.
Meyer et al, "Synthesis and Biological Activity of Several 6-Substituted 9-.beta.-D-Ribofuranosylpurine 3', 5'-Cyclic Phosphates," Biochemistry, vol. 11, No. 14, (1972).
Miller et al, "Synthesis and Enzymatic and Inotropic Activity of Some New 8-Substituted and 6,8-Disubstituted Derivatives of Adenosine Cyclic 3', 5'-Monophosphate," J. Med. Chem., 23, 242-251 (1980).

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