Process for preparation of MR contrast agents

Details Process for preparation of MR contrast agents Process for preparation of MR contrast agents

2005-03-29

2005-03-29

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C560S231000

Reexamination Certificate

active

06872380

ABSTRACT:
The present invention provides a process for the preparation of an MR contrast agent, said process comprising:i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound;ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent;iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength;iv) optionally dissolving said imaging agent in an aqueous medium;v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium;vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; andvii) optionally freezing the solution of said imaging agent in said aqueous medium.

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U.S. Provisional application No. 60/066,570, Golman et al., filed Nov. 1997.*
U.S. Provisional application No. 60/076,924, Golman et al., filed Mar. 1998.*
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