Process for preparation of macrocyclic chelants and the chelates

Details Process for preparation of macrocyclic chelants and the chelates Process for preparation of macrocyclic chelants and the chelates

1999-05-24

2000-04-04

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540472, 540465, 424 9363, C07D48722, A61B 5055

Patent

active

060463244

ABSTRACT:
A process for the preparation of complexes of macrocyclic chelants with paramagnetic metal trivalent ions of formula (XII) ##STR1## wherein R.sub.1, R.sub.2 and Me.sup.3+ are as described in the following, comprising: a) reaction of 1,4,7,10-tetraazacyclododecane with triethyl orthoformate to give 5H,9bH-2a,4a,7,9a-octahydrotetraazacycloocta[cd]pentalene; b) carboxymethylation reaction in water; c) hydrolysis reaction in basic conditions; d) alkylation according to known methods with an epoxide in water; e) complexation according to known methods carried out in water by addition of a paramagnetic metal salt; f) purification by diafiltration, final desalting of the aqueous solution on ion exchange resins and g) crystallization or recovery.

REFERENCES:
patent: 4085106 (1978-04-01), Atkins
patent: 5277895 (1994-01-01), Platzek et al.
patent: 5447635 (1995-09-01), Viscardi et al.
patent: 5747000 (1998-05-01), Platzek et al.
patent: 5925752 (1999-07-01), Ripa et al.
Dischino et al Inorg. Chem. 1991, 30, pp. 1265-1269 Synthesis of Gadolinium (+)-10-(1-Hydroxypropan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyltr iacetate etc.
Weisman et al Tetrahedron Letters vol. 21, 1980 pp. 3635-3638.

Affiliated with

Also associated with

Rating

Process for preparation of macrocyclic chelants and the chelates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparation of macrocyclic chelants and the chelates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of macrocyclic chelants and the chelates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-366511