Process for preparation of ketones

Details Process for preparation of ketones Process for preparation of ketones

1994-04-26

1996-01-02

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

568394, 568346, 568314, C07C 6710

Patent

active

054810299

ABSTRACT:
A process for preparing ketones, for example CF.sub.3 C(O)CH.sub.3, CF.sub.3 C(O)CH.sub.2 C(O)CF.sub.3 and CF.sub.3 C(O)CF.sub.2 H, in which .beta.-ketoesters are transesterified and decarboxylated using a carboxylic acid, for example trifluoroacetic acid, in the presence of a catalyst, particularly an "onium" salt of a carboxylic acid or an effective amount of a proton-donating acid, preferably a sulfonic acid such as alkyl- or arylsulfonic acids, or a mineral acid. The process is advantageously carried out in the absence of water, so that no formation of acetals or hydrates occurs, and no dehydrating step is needed. The process is simple to carry out, and if transesterification is carried out with a sufficiently active carboxylic acid, for example with trifluoroacetic acid, the presence of an additional catalyst is unnecessary.

REFERENCES:
patent: 2369250 (1945-02-01), Reeder et al.
patent: 4276225 (1981-06-01), Lantzsch et al.
patent: 5093532 (1992-03-01), Baasner et al.
patent: 5210272 (1993-05-01), Palmer
patent: 5274136 (1993-12-01), Mills et al.
Hudson et al., J. A. C. S., 63:3163-4 (1941).
Henne et al., J. A. C. S., 69:1819.varies.20 (1947).
Chemical Abstracts, 107:197496y (1987).
Japanese High Technology Monitor, vol. 10, no. 2, p. 3, Entry No. 31607 (1987).
Kal'fa et al., "New method for . . . ", J. Fluorine Chem., 58:358 (1992) P90.

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