Process for preparation of glycosides of tumor-associated carboh

Details Process for preparation of glycosides of tumor-associated carboh Process for preparation of glycosides of tumor-associated carboh

1997-03-18

2000-01-11

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 185, 530322, 530350, C07H 100

Patent

active

060137797

ABSTRACT:
Glycoconjugate antigens are prepared by preparing a hapten glycoside, especially an alpha glycoside prepared by the Fischer method, with an olefinic aglycon moiety, especially one having a non-terminal double bond, ozonolyzing the hapten glycoside with an olefinic aglycon moiety having a non-terminal double bond to form a hapten-glycoside derivative, preferably without producing Germaldehyde as a byproduct removing by-products of ozonolysis, and conjugating the hapten-glycoside derivative to a carrier.

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