Process for preparation of di- or trifluoromethoxyphenyl ketones

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260465G, 562426, 564329, 568 43, 568306, 568319, 568322, C07C12175, C07C 4543, C07C14900

Patent

active

044380437

ABSTRACT:
A process for the preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones, characterized in that, in a first stage, a di- or trihalomethoxybenzene or a di- or trihalomethylthiobenzene is reacted with a trihalomethylated aromatic or aliphatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent and in that, in a second stage, the product of the first stage is hydrolyzed. The resultant products are useful as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

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