Process for preparation of D-lactic acid from D,L lactic acid es

Details Process for preparation of D-lactic acid from D,L lactic acid es Process for preparation of D-lactic acid from D,L lactic acid es

1995-06-07

1997-02-25

Marx, Irene

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435139, C12P 4100

Patent

active

056058330

ABSTRACT:
A process is disclosed for the preparation of D-lactic acid from lactate racemic mixture. It comprises the steps of: (i) hydrolysis of an alkyl lactate racemic mixture in the presence of an esterase as a catalyst to hydrolyze L-alkyl lactate; (ii) separation of unhydrolyzed D-alkyl lactate with an organic solvent, such as n-hexane or a high alcohol; and (iii) chemical hydrolysis of the separated portion obtained from step (ii) with a base to obtain D-lactic acid. The esterase can be selected from the group consisting of pig pancreas lipase of the trade name Sigma L-3126, wheat germ lipase of the trade name Sigma L-3001, Candida cyclindracea lipase of the trade name Sigma L-1754, Rhizopus lipase of the trade name Serva 27930, Mucor javanicus lipase of the trade name Fluca 62304, Aspergillus niger lipase of the trade name Fluca 62301, Rhizopus arrhizus lipase of the trade name Boehringer Mannherin 414590, and Candida cylindracea cholesterol esterase of the trade name Boehringer Mannherin 396800.

REFERENCES:
patent: 5061629 (1991-10-01), Coffen et al.
patent: 5248610 (1993-09-01), Miyazawa et al.
Parida S. et al., J. Org. Chem. 58: 3238-44 (1993).
Enzyme Nomenclature, Academic Press, Inc., pp. 270-273 (1984).
ATCC Catalogue of Filamentous Fungi pp. 365, 367 (1991).
Cambou B, Biotech Bioengin. vol. XXVI: 1449-54 (1984).

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