Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2007-03-20
2007-03-20
Berch, Mark L. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
active
10436799
ABSTRACT:
The method of preparing compounds of Formula I is described:wherein:M and V are cis to one another and MPO3H2is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, and (R)-9-(2-phosphonylmethoxypropyl)adenine; wherein V is phenyl, optionally substituted with 1–2 substituents selected from a group consisting of fluoro, chloro, and bromo; comprising: coupling a chiral 1-phenylpropane-1,3-diol, wherein the phenyl may be optionally substituted, with MPOCl2or an N-6 substituted analogue thereof.Additionally, methods and salt forms are described that enable isolation and purification of the desired isomer.
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Kopcho Joseph J.
Matelich Michael C.
Reddy K. Raja
Ugarkar Bheemarao G.
Berch Mark L.
Metabasis Therapeutics, Inc.
Sterne Kessler Goldstein & Fox P.L.L.C.
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