Process for preparation of chiral amlodipine salts

Details Process for preparation of chiral amlodipine salts Process for preparation of chiral amlodipine salts

2005-01-25

2005-01-25

Morris, Patricia L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06846932

ABSTRACT:
A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(−) Amlodipine and R(+) Amlodipine from without isolation of a free base from with optical purity rank between 96-99% is described in the present invention. The process comprises resolving RS amlodipine base using of L(+) or D(−) tartaric acid to obtain salt of corresponding to the acid used in ee rang from 96-99%.

REFERENCES:
patent: 6046338 (2000-04-01), Spargo
patent: 6608206 (2003-08-01), Joshi et al.

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