Process for preparation of celecoxib

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S373100

Reexamination Certificate

active

07919633

ABSTRACT:
There is provided a process for preparation of celecoxib by reacting 4,4,4-trifluoro-1-[4-(methyl)phenyl]butane-1,3-dione with 4-sulphonamidophenylhydrazine or its salt in a solvent medium that contains an alkyl ester. There is also provided a process for the purification of celecoxib using aromatic hydrocarbon solvents.

REFERENCES:
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patent: 5563165 (1996-10-01), Talley et al.
patent: 7141678 (2006-11-01), Letendre et al.
patent: 7759497 (2010-07-01), Letendre et al.
Letendre et al (2003): STN International HCAPLUS database, (Columbus, Ohio), Accession No. 2003:951004.

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