Process for preparation of cefuroxime ester

Details Process for preparation of cefuroxime ester Process for preparation of cefuroxime ester

1988-10-18

1991-02-19

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50112

Patent

active

049945670

ABSTRACT:
There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.
Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.
Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.

REFERENCES:
patent: 4002748 (1977-01-01), Bornstein et al.
patent: 4267320 (1981-05-01), Gregson et al.
patent: 4562181 (1985-12-01), Crisp et al.

Affiliated with

Also associated with

Rating

Process for preparation of cefuroxime ester does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparation of cefuroxime ester, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of cefuroxime ester will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1144833