Process for preparation of bicyclic and polycyclic molecules

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S091000, C546S127000, C546S131000

Reexamination Certificate

active

07012142

ABSTRACT:
The present application is directed to a method of synthesis of a bicyclic or polycyclic compound of formula I or formula II:in which E, G, Y, n, m, R, R1, R2, R3, R6, R7, R8and R9are as defined.

REFERENCES:
patent: WO 97/40859 (1997-11-01), None
patent: WO 99/02526 (1999-01-01), None
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Molander, G.A., et al., “Sequenced Reactions with Samarium (II) Iodide. Intermolecular Ketyl-Olefin Coupling/Intramolecular Nucleophilic Acyl Substitution for the Preparation of Six-, Seven-, and Eight-Membered Carbocycles.”,Tetrahedron, 54, 9289-9302, (1998).
A. Kozikowski, et al., “Synthesis of 8-Oxa Analogues of Norcocaine Endowed with Interesting Cocaine-like Activity”,Bioorganic&Medicinal Chemistry Letters, vol. 9, pp. 1831-1836 (1999).
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P.C. Meltzer et al., “Structure Activity Relationships of Inhibition of the Dopamine Transporter by 3-Arylbicyclo [3.2.1] Octanes”,Medicinal Chemistry Research, vol. 8, No. 1/2 pp. 12-34 (1998).
I. P. Kovalev et al., “Catalytic Codimerization of α, β- with γ, σ-Unsaturated Ketones: Novel Stereoselective Method of the Synthesis of Functionalized 8-Oxabicyclo [3.2.1] octanes”,Tetrahedron Letters, vol. 33, No. 13, pp. 1791-1794, (1992).
K. G. Bowers, et al., “Thromboxane A2Analogues from 8-Oxabicyclo[3.2.1]oct-6-en-3-ones”,J. Chem. Soc. Perkin Trans.I, pp. 1657-1666, (1987).
P. Brownbridge et al., “A Simple Route to the 8-Oxabicyclo [3.2.1] Octyl and 9-Oxabicyclo [3.3.1] Nonyl Systems. Synthesis of the 8-Oxa Analog of Cocaine”,Tetrahedron Letters, No. 46, pp. 4437-4440, (1979).

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