Process for preparation of Bicalutamide

Details Process for preparation of Bicalutamide Process for preparation of Bicalutamide

2006-10-17

2009-06-09

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C558S303000

Reexamination Certificate

active

07544828

ABSTRACT:
A process for preparation of Bicalutamide of formula (I),comprising oxidation of compound of formula (II),with potassium permanganate in presence of water or a mixture of water and water miscible solvent and isolating Bicalutamide of formula (I) thereof.

REFERENCES:
patent: 4636505 (1987-01-01), Tucker
patent: 6740770 (2004-05-01), Shintaku et al.
patent: 2004/0013303 (2004-01-01), Lienhart et al.
patent: 2004/0063782 (2004-04-01), Westheim
patent: 01/00608 (2001-01-01), None
patent: 02/24638 (2002-03-01), None
patent: 2004/074350 (2004-09-01), None
patent: 2005/037777 (2005-04-01), None
“Oxidizing agent,” http://en.wikipedia.org/wiki/Oxidizing—agent, Retrieved online via Internet, Sep. 22, 2008.
Tucker et al. “Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides” vol. 31, No. 5 p. 954-959 (1988).

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