Process for preparation of .beta.-lactam derivatives

Details Process for preparation of .beta.-lactam derivatives Process for preparation of .beta.-lactam derivatives

1987-05-12

1990-07-03

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540225, 540226, 540227, 540300, 540301, 540350, C07D50104

Patent

active

049392506

ABSTRACT:
A process for preparing compounds of the formula I: ##STR1## wherein X is sulphur, oxygen, methylene or sulphinyl (R or S configuration), R.sup.3 is hydrogen or methoxy, R.sup.4 is an optionally substituted (1-4C)alky group, Y is hydrogen or a carboxyl protecting group and Q is an optionally protected amino group or an acylamino group, which comprises reacting a compound of formula (II) ##STR2## with a compound of formula (III) ##STR3## wherein R.sup.4 is as defined above and W and Z represent hydrogen atoms or a group or groups removable to yield the compound of formula (I). The compounds of the formula I are useful intermediates in the preparation of cephalosporin antibiotics.

REFERENCES:
patent: 4464368 (1984-08-01), O'Callaghan et al.
patent: 4678781 (1987-07-01), Jung
patent: 4748171 (1988-05-01), Yamauchi et al.
J. Org. Chem. 1988, 53, 983-991.
Merck Index, p. 271.
Merck Index, p. 276.

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