Process for preparation of beta-lactam derivatives

Details Process for preparation of beta-lactam derivatives Process for preparation of beta-lactam derivatives

1989-03-01

1990-05-15

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D49908, A61K 31425

Patent

active

049259342

ABSTRACT:
The invention provides a process for preparing a .beta.-lactam derivative represented by the formula ##STR1## the process comprising reacting a .beta.-lactam derivative represented by the following formula (II) and having a protected carboxyl group with a cresol; ##STR2## wherein R represents a benzyl group having an electron-donating group as a substituent on the phenyl ring, a diphenylmethyl group which may have an electron-donating group as a substituent on the phenyl ring or a tert-butyl group.

REFERENCES:
Kametani, T. et al., "The Deblocking of Cepalosporin Benzhydryl Esters with Formic Acid", Chemical Pharmaceutical Bulletin, vol. 30, No. 12 (1982), pp. 4545-4547.
Tsuji, T. et al., "Synthetic Studies on .beta.-Lactam Antibiotics VII", Tetrahedron Letters, No. 30, pp. 2793-2796.
Journal of The American Chemical Society, No. 91, Sep. 24, 1969, pp. 5674-5675.

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