Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1994-09-20
1996-11-26
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544238, 544288, 544335, 544336, 544353, 544354, 544408, 546 98, 546101, C07D23700, C07D22106, C07D23902, C07D23972
Patent
active
055787240
ABSTRACT:
A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5.alpha.-reductase and their preparation is disclosed.
REFERENCES:
patent: 5017568 (1991-05-01), Holt et al.
patent: 5030636 (1991-07-01), Inhof et al.
patent: 5239075 (1993-08-01), Audia et al.
patent: 5300294 (1994-04-01), Johnson
patent: 5302621 (1994-04-01), Kojima
Cannon, et al., J. Med. Chem., 22, 341-347 (1979).
Cannon, et al., J. Med Chem., 19, 987-993 (1976).
Cannon, et al., J. Pharm. Sci., 74, 672-675 (1985).
Cannon, et al., Synthesis., 494-496 (1986).
Audia, et al., Tetra. Ltrs., 34, 7001-7004 (1993).
Hirsch, et al., Proc. Natl. Acad. Sci., 90, 5277-5281, (1993).
Jones, et al., J. Med. Chem., 36, 421-423 (1993).
Wikel, et al., Biorganic & Med. Chem. Ltrs., 3, 1157-1162 (1993).
Andersson, et al., Nature, 354, 159-161 (1991).
Jenkins, et al., J. Clin.. Invest., 89, 293-300 (1992).
George, et al., Proc. Natl. Acad. Sci., 88, 8044-8047 (1991).
Andersson and Russell, Proc. Natl. Acad. Sci., 87, 3640-3644 (1990).
Starks and Liotta, "Phase Transfer Catalysis", Academic Press, N.Y., 1978, p. 217.
Koziara, et al., Synthesis, 527-529 (1979).
Klein, et al., J. steroid Biochem., 30 (1-6), 119-130 (1988).
Kadohama, et al., JNCI, 74 (2), 475-486 (1985).
Brooks, et al., The Prostate, 18, 215-227 (1991).
Andriole, et al., The Prostate, 10, 189-197 (1987).
Gormley, Glenn J., Urol. Clin. North America, 18 (1), 93-98 (1991).
Haehl Kevin L.
Kress Thomas J.
Wepsiec James P.
Barrett Brian P.
Boone David E.
Eli Lilly and Company
Huang Evelyn
Ivy C. Warren
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