Process for preparation of azetidinone derivatives

Details Process for preparation of azetidinone derivatives Process for preparation of azetidinone derivatives

1984-12-12

1987-12-15

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20508, C07B 4500, C07F 965, C07F 710

Patent

active

047134526

ABSTRACT:
A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formula

REFERENCES:
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Houben-Weyl, Meth. Org. Chem., vol. 9, (1955), pp. 72-73.
Fugisawa, Chemical Abstracts, vol. 98, No. 23, 6 Jun. 1983, p. 620, abstract no. 197890t.

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