Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Reexamination Certificate
2009-10-21
2010-12-07
Witherspoon, Sikarl A (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C568S314000, C568S328000
Reexamination Certificate
active
07847127
ABSTRACT:
Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as “Form IPCA-ATO,” and the preparation thereof.
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Buchude Vitthal Suryabhan
Byju Nellithanath Thankachen
Dike Suneel Yeshwant
Kore Swapnil Shreekant
Kumar Ashok
Blank Rome LLP
IPCA Laboratories Limited
Witherspoon Sikarl A
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