Process for preparation of aspartylphenylalanine alkyl esters

Details Process for preparation of aspartylphenylalanine alkyl esters Process for preparation of aspartylphenylalanine alkyl esters

1983-08-03

1986-05-06

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435 68, 435220, 435874, 435877, 435253, C12P 2100, C12P 2102, C12N 952, C12R 140

Patent

active

045872147

ABSTRACT:
.alpha.-L-aspartylphenylalanine lower alkyl esters are prepared by a process wherein fumaric acid, ammonia and a lower alkyl ester of L-phenylalanine are contacted with a culture or treated culture of a microorganism belonging to the genus Pseudomonas, and being capable of producing a .alpha.-L-aspartyl-L-phenylalanine lower alkyl ester from fumaric acid, ammonia and a lower alkyl ester of L-phenylalanine.

REFERENCES:
patent: 4256836 (1981-03-01), Isowa et al.
patent: 4335205 (1982-06-01), Greenwood
Morrison and Boyd Organic Chemistry, 1973, Allan & Bacon Inc., p. 870.

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