Process for preparation of antisera

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

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260112B, 424 15, 424 9, 424 12, 424 85, 424 88, A61K 3348, A61K 4900, A61K 4300, C07G 700

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active

042798841

ABSTRACT:
A process for the preparation of a high titre antiserum of a desired specificity includes the steps of, a first immunological reaction between a serum sample which includes a protein to which the required antiserum is specific and an antiserum sample known to include the required antiserum, injecting into an animal a first selected antigen/antibody comples from the aforesaid first reaction, withdrawal of serum from the animal, performing a second immunological reaction between the withdrawn serum and a serum sample which includes the protein to which the required antiserum is specific, and selecting a second antigen/antibody comples from the second reaction, the first and second selected complexes including the required antiserum.

REFERENCES:
patent: 3284434 (1966-11-01), Sutherland
patent: 4026879 (1977-05-01), Spector
patent: 4041076 (1977-08-01), Avenia et al.
Smith et al., Immunology, 7, p. 111 (1964).
Shivers et al., Immunology 13, p. 547 (1967).
Crowle et al., Immunological Communications, 1 (4), 1972, pp. 325-336.
Nansen et al., Acta Patn. Microbiol. Scand., Section B. 79, 1971, pp. 459-465.

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