Process for preparation of an optically active monoalkyl ester o

Details Process for preparation of an optically active monoalkyl ester o Process for preparation of an optically active monoalkyl ester o

1981-12-08

1983-11-15

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435135, 435280, 435830, 435832, 435840, 435843, 435859, 435872, 435874, 435882, 435885, 435911, 435912, 435913, 435921, 435929, 435931, 435932, 435933, 435938, 435939, C12P 1304, C12P 762, C07B 1902

Patent

active

044156570

ABSTRACT:
A process is disclosed in which an optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is prepared by subjecting a dialkyl ester of .beta.-protected aminoglutaric acid to the action of a culture broth, cells, or treated cells of a microorganism capable of stereoselectively hydrolyzing only one of the ester groups in the above-mentioned dialkyl ester to produce an optically active monoalkyl ester of .beta.-protected (S)-aminoglutaric acid, and then removing the amino-protecting group from the product. An optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is useful as a starting material for synthesizing .beta.-lactam antibiotics of carbapenem type such as thienamycin.

REFERENCES:
patent: 4242452 (1980-12-01), Yamada et al.
patent: 4302541 (1981-11-01), Hirata et al.
patent: 4332905 (1982-06-01), Olivieri et al.
Ohno et al., Journal American Chemical Society, vol. 103, pp. 2405-2406, (1981).

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