Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1995-12-19
1997-12-02
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
435106, 435910, C12P 1324, C12P 1304
Patent
active
056935030
ABSTRACT:
This invention provides a process for preparation of trans-4-hydroxy-L-proline which comprises either culturing Xanthomonas maltophilia NA-62 (FERM BP-4479), Xanthomonas maltophilia JCM No.3807 (FERM BP-4474) or Xanthomonas sp. JCM No.3857 (FERM BP-4475) in a nutrient medium containing collagen or gelatin or a partial hydrolyzate of collagen or gelatin, or contacting culture cells of the above microorganism with collagen or gelatin or a partial hydrolyzate of collagen or gelatin in an aqueous medium, and recovering trans-4-hydroxy-L-proline formed; and a process for preparation of an amino acid mixture which comprises contacting culture cells, fractured cells before or after removal of the broken pieces of the cells, or a crude enzyme obtained by subjecting the fractured cells after removal of the broken pieces of the cells to salting-out or solvent precipitation, from Xanthomonas maltophilia NA-62 (FERM BP-4479), Xanthomonas maltophilia JCM No.3807 (FERM BP-4474) or Xanthomonas sp. JCM No.3857 (FERM BP-4475), with collagen or gelatin or a partial hydrolyzate of collagen or gelatin in an aqueous medium, and recovering the amino acid mixture formed. Trans-4-hydroxy-L-proline, and an amino acid mixture containing trans-4-hydroxy-L-proline and L-proline in a high concentration are efficiently produced by this invention.
REFERENCES:
patent: 4224409 (1980-09-01), Nakamori et al.
patent: 4444885 (1984-04-01), Nakanishi et al.
patent: 4455372 (1984-06-01), Chibata et al.
patent: 5364775 (1994-11-01), Katsumata et al.
patent: 5374542 (1994-12-01), Katsumata et al.
Kanamori Hironori
Miyoshi Shinsuke
Sato Manami
Lilling Herbert J.
Showa Sangyo Co. Ltd.
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