Process for preparation of a new hemin complex

Details Process for preparation of a new hemin complex Process for preparation of a new hemin complex

1985-12-02

1991-04-16

Stone, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

530400, C07B 4700, C07K 300

Patent

active

050083880

ABSTRACT:
The present invention relates to a method for the preparation of a new, physiologically active, water-soluble complex compound, hemin arginate or hemin lysinate. According to the invention crystalline hemin and one of the amino acids L-arginine or L-lysine, in a molar proportion of 1:3, are allowed to react at room temperature under vigorous stirring for 10 to 15 hours in a solvent mixture of acetone and water in a ratio of 300:20 v/v. The hemin arginate or hemin lysinate thus formed is a powdery, stable compound suitable for use as raw material in tablets or capsules or as dry substance for preparation of injections for treatment of various types of anemia, including iron deficiency anemia and anemias and diseases associated with defects in heme synthesis.

REFERENCES:
patent: 4431581 (1984-02-01), Lindroos
Wakid N. W. & Helou K. Y.: Int. J. Biochem. 4: 259-267, 1973.
Yamagishi et al., Chem. Abstracts, vol. 96:64451n (1982).
Livshits et al., Chem. Abstracts, vol. 87:53549p (1977).
Nanzyo et al. J. Biol. Chem., pp. 3431-3440, vol. 243, No. 12, 1968.

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