Process for preparation of a 1-(tetrazolylbiphenylmethyl)-imidaz

Details Process for preparation of a 1-(tetrazolylbiphenylmethyl)-imidaz Process for preparation of a 1-(tetrazolylbiphenylmethyl)-imidaz

1998-01-09

2000-03-21

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D25704

Patent

active

06040454&

ABSTRACT:
The invention is directed to a process for preparing a 5-substituted tetrazole, the process comprising the step of reacting a nitrile with an inorganic azide salt in an aromatic hydrocarbon solvent in the presence of an amine salt. According to the invention, a 5-substituted tetrazole can be produced in a high yield with ease and safety using inexpensive raw materials while the reaction is easily controlled to inhibit a side reaction.

REFERENCES:
patent: 2977372 (1961-03-01), Finnegan et al.
patent: 4791210 (1988-12-01), Bison et al.
Finnegan et al., "An Improved Synthesis of 5-Substituted Tetrazoles", Journal American Chem. Soc., vol. 80, pp. 3908-3911, (1958).
Herbst et al., "Apparent Acidic Dissociation of Some 5-Aryltetrazoles", Journal Org. Chem., vol. 22, pp. 142-1145, (1957).
Duncia et al., "Three Synthetic Routes to a Sterically Hindered Tetrazole. A New One-Step Mild Conversion of an Amide into a Tetrazole", Journal Org. Chem., vol. 56, pp. 2395-2400, (1991).

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