Process for preparation of 9-(dihalobenzyl) adenines

Details Process for preparation of 9-(dihalobenzyl) adenines Process for preparation of 9-(dihalobenzyl) adenines

1977-02-14

1978-07-04

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424253, 544254, 544329, C07D47334

Patent

active

040987876

ABSTRACT:
9-(Dihalobenzyl)adenines are prepared uncontaminated with other positional isomers in a series of mild transformations starting from 4,5,6-triaminopyrimidine and proceeding via 7-(N-formyl-N-dihalobenzyl)amino[1,2,5]thiadiazolo[3,4-d]pyrimidine. The resulting compounds have anticoccidial activity and are useful in controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.

REFERENCES:
taylor et al., J. Chem. Soc., 36 3211-3217, (1971).
Shealey et al., J. Org. Chem., 27 2154-2160, (1962).

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