Process for preparation of 9-(2,6-dihalobenzyl)adenines

Details Process for preparation of 9-(2,6-dihalobenzyl)adenines Process for preparation of 9-(2,6-dihalobenzyl)adenines

1977-02-07

1978-07-11

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424253, C07D47334

Patent

active

041001591

ABSTRACT:
9-(2,6-Dihalobenzyl)adenines are prepared by allowing 2,6-dihalobenzyl halides to react with a salt of adenine in a solid-liquid or liquid-liquid two phase system in the presence of an onium salt phase transfer catalyst. The resulting compounds have anticoccidial activity and are useful in controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.

REFERENCES:
patent: 3846426 (1974-11-01), Lira et al.
patent: 3953597 (1976-04-01), Lira et al.
patent: 3992432 (1976-11-01), Napier et al.
Durst et al., J. Org. Chem., 39, 3271 (1974).
Landini et al., Synthesis, 389 (1976).
Gokel et al., Aldrichimica, Acta, 9, 3 (1976).
Jones, Aldrichimica, Acta, 9, 35 (1976).
Dehmlow, Chemtech, 210-218 (1975).
Starks, J. Amer. Chem. Soc., 93:1 (1971).

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