Process for preparation of 7-[α-amino...

Details Process for preparation of 7-[α-amino... Process for preparation of 7-[α-amino...

2006-02-23

2008-09-23

Puttlitz, Karl J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid anhydrides

C562S893000, C562S888000

Reexamination Certificate

active

07427692

ABSTRACT:
A process for preparation of 7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid viz. Cefprozil of formula (I) in high purity, substantially free of impurities,which comprises preparation of mixed acid anhydride by selecting the sequence and temperature of addition of the reagents and its subsequent condensation with a protected 7-APCA; followed by hydrolysis, isolation and purification to give Cefprozil of formula (I) in the form of a monohydrate.

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