Process for preparation of 7-alkoxy-3-chloromethylcephems

Details Process for preparation of 7-alkoxy-3-chloromethylcephems Process for preparation of 7-alkoxy-3-chloromethylcephems

1976-03-22

1977-09-13

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50104, A61K 31545

Patent

active

040481638

ABSTRACT:
7-Alkoxy-3-chloromethyl-3-cephems are provided by reacting a 3-methylenecepham with an alkali metal salt of a lower primary alcohol in the presence of tert-butyl hypochlorite at a temperature ranging from about -80.degree. to about 0.degree. C. The 3-chloromethylcephems provided by this invention are useful intermediates for the preparation of known cephalosporin antibiotics.

REFERENCES:
patent: 3637678 (1972-01-01), Webber et al.
patent: 3658799 (1972-04-01), Eardley et al.
patent: 3705897 (1972-12-01), Murphy
Kobbel et al., JACS., vol. 95, 2403 (1973).
Karady et al., Tetrahedron Letters, vol. 30, 2625(1974).

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