Process for preparation of 6-substituted 5-fluorouracil derivati

Details Process for preparation of 6-substituted 5-fluorouracil derivati Process for preparation of 6-substituted 5-fluorouracil derivati

1972-07-13

1976-05-04

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602564C, 424251, C07D23922

Patent

active

039547590

ABSTRACT:
The reaction of certain fluorinated pyrimidine derivatives with hydrogen donor compounds to produce 6-substituted 5-fluoropyrimidines is disclosed. The products so produced are useful in germicidal and antineoplastic applications, and can be converted into 5-fluorouracil, which has known utility in cancer chemotherapy.

REFERENCES:
patent: 3221010 (1965-11-01), Duschinsky et al.
patent: 3277092 (1966-10-01), Duschinsky et al.
patent: 3682917 (1972-08-01), Knuniants et al.

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