Process for preparation of 5H-dibenzo[a,d] cycloheptene...

Details Process for preparation of 5H-dibenzo[a,d] cycloheptene... Process for preparation of 5H-dibenzo[a,d] cycloheptene...

2006-12-11

2008-11-04

Barts, Samuel A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

07446227

ABSTRACT:
A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.

REFERENCES:
patent: 3332977 (1967-07-01), Wendler
patent: 5616716 (1997-04-01), Dull et al.
patent: 5932767 (1999-08-01), Hoerrner et al.
patent: 11034486 (1966-06-01), None
Caporusso et al, Stereoselective Synthesis of Chiral 3-Aryl-1-alkynes from Bromoalienes and heterocuprates, 2006, Published on Web (Sep. 2, 2006), J. Org. Chem., vol. 71, pp. 1902-1910, especially p 1907, para. D.

Affiliated with

Also associated with

Rating

Process for preparation of 5H-dibenzo[a,d] cycloheptene... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparation of 5H-dibenzo[a,d] cycloheptene..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of 5H-dibenzo[a,d] cycloheptene... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4045639