Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2008-01-08
2011-12-06
Murray, Jeffrey (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
active
08071767
ABSTRACT:
Described herein is an improved, commercially viable and industrially advantageous process for the preparation of paliperidone intermediate 9-hydroxy-3-(2-chloroethyl)-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one and its hydrochloride salt. The process provides the paliperidone intermediate in higher yield and reduced reaction time compared to the previously disclosed processes, thereby providing for production of paliperidone and its pharmaceutically acceptable acid addition salts in high purity and in high yield.
REFERENCES:
patent: 4804663 (1989-02-01), Kennis et al.
patent: 5158952 (1992-10-01), Janssen et al.
patent: 5254556 (1993-10-01), Janssen et al.
patent: 5688799 (1997-11-01), Vandenberk et al.
patent: 0368388 (1989-10-01), None
patent: 9514691 (1995-06-01), None
patent: WO/9623784 (1996-08-01), None
patent: 2006027370 (2006-03-01), None
Kennis, et. al., Bioorganic & Medicinal Chemistry Letters (2000), 10(1), 71-74.
International Search Report and Written Opinion; International Application No. PCT/IB2008/000626; International Filing Date Jan. 8, 2008; Date of Mailing: Dec. 18, 2008; 16 pages.
DeSMET, et al.; “Selectivity Control by Use of Near-IR for a Hydrogenation Process”; Organic Process Research & Development; 9; pp. 344-347; (2005).
Badawey, et. al.; “Synthesis of Some New Imidazo[1,2-a]pyrimidin-5(1H)-ones as Potential Antineoplastic Agents”; Journal of Heterocyclic Chemistry; 32; pp. 1003-1006; (1995).
Bapat Uday Rajaram
Jayamani Munusamy
Ravisankar Vigneshwara
Ravisaravanan Sivaji
Actavis Group PTC EHF
Cantor & Colburn LLP
Murray Jeffrey
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