Process for preparation of 3 piperazinylbenzisothiazoles

Details Process for preparation of 3 piperazinylbenzisothiazoles Process for preparation of 3 piperazinylbenzisothiazoles

1997-09-26

1999-01-19

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D41704

Patent

active

058615113

ABSTRACT:
There is disclosed a process for preparing 3-piperazinylbenzisothiazoles comprising reacting the specified 3-halo-1,2-benzisothiazole or 2-cyanobenzenesulfenyl halide in the presence of an alkylene glycol derivative. The process is industrially effective, easy and economical and can provide useful intermediates for production of pharmaceutical preparations.

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Abstract for JP 63-83067, Apr. 3, 1988.
Abstract for JP 63-83005, Apr. 3, 1988.
Bryce, M. R., et al., J. Chem. Soc. Perkin Trans. I, 1 (8), 2141-2144 (1988).
Yevich, J. P., et al., J. Med. Chem., 29, 359-369 (1986).

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