Process for preparation of 3-piperazinylbenzisothiazoles

Details Process for preparation of 3-piperazinylbenzisothiazoles Process for preparation of 3-piperazinylbenzisothiazoles

1998-08-04

1999-08-17

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D41704

Patent

active

059395486

ABSTRACT:
There is disclosed a process for preparing 3-piperazinylbenzisothiazoles comprising reacting the specified 3-halo-1,2-benzisothiazole or 2-cyanobenzenesulfenyl halide in the presence of an alkylene glycol derivative. The process is industrially effective, easy and economical and can provide useful intermediates for production of pharmaceutical preparations.

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patent: 5756806 (1998-05-01), Goda et al.
HRIB et al., J. Med. Chem. vol.39, pp.4044-4057, 1996.
Bryce, M. R., et al., J. Chem. Soc. Perkin Trans. I, 1(8), 2141-2144 (1988).
Yevich, J. P., et al., J. Med. Chem. 29, 359-369 (1986).
Abstract of JP 63083067 (Apr. 13, 1988).
Abstract of JP 63083085 (Apr. 13, 1988).

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