Process for preparation of 3-hydroxymethylcephems

Details Process for preparation of 3-hydroxymethylcephems Process for preparation of 3-hydroxymethylcephems

1976-04-19

1977-07-26

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50104

Patent

active

040382753

ABSTRACT:
3-Hydroxymethyl-2-cephems are provided by (1) reacting a 2-halomethylcephem compound with a .gamma.-hydroxycarboxylic acid salt or a .delta.-hydroxycarboxylic acid salt and (2) reacting the novel .gamma. or .delta.-hydroxy esters thereby obtained with a protic acid. The 3-hydroxymethylcephems provided by the process of this invention are useful intermediates for the preparation of known cephalosporin antibiotics.

REFERENCES:
patent: 3948906 (1976-04-01), Eardley et al.
patent: 3950329 (1976-04-01), Boswell et al.

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